Effects Of Kratom Alkaloids

Kratom has some alkaloids that impart various properties and effects. The interaction of all alkaloids delivers these results. The alkaloids are the active ingredients in Kratom. Different alkaloids have diverse empathies for the Opiate receptors as some have stronger affinity while others don’t.

By connection with receptors and inducing a reaction, the alkaloids are categorized into two major categories. The two most active alkaloids that re primarily accountable for the effects are;

  • 7-hydroxy-mitragynine
  • Mitragynine

Alkaloids present in excessive amounts in Kratom strains such as Wekratom.com Maeng DaIndo MalaysianBali, and Borneo. Mitragynine is the primary active ingredient which acts on the Opiate brain receptors named as delta, kappa, and mu.

  • Alkaloids produce vitality and strength due to Maeng Da, Malay and Thai strains without producing a frazzled mood.
  • The well-known sedative strains of Kratom that produce sedation are Indo, Bali, and Borneo with the high quantity of the alkaloids.
  • The alkaloids with the firmest empathy for mu and kappa Opiate receptors are known to cause euphoria and an overall boost in mood.
  • The strains for boosting mood include; Malay, Bali, Borneo Indo and Maeng Da


It is an active ingredient of Kratom and considered thirty times more efficient than mitragynine and 13 times stronger than morphine. It causes physical dependence, insensitivity and quickly develops tolerance.

Side Effects:

Harmful effects produced by Hydroxymitragynine are infrequent.

At low doses, it causes;

  • Analgesia
  • Euphoria
  • Enhanced cognition

While at high doses it can be described as relaxing and sedative.


The most active alkaloid is Mitragynine in kratom that acts as a powerful stimulant and owns both stimulating and relaxing effects determined by the quantity consumed.

General effects stated from alkaloid consumption include;

  • Intense concentration
  • High focus
  • Physical energy
  • Mental strength
  • Stress relief
  • Muscle relaxation
  • Reduce depression
  • Ease anxiety
  • Improved immune reaction
  • Good sleep
  • Expressive moods of joy and euphoria
  • Confidence

Mitragynine Faction & Side Effects:

Side effects are minor in general such as little antagonistic effects due to high doses. Sometimes it shows specific drug interactions, therefore, conjunction with other medications is not recommended.

The symptoms include;

  • Nausea
  • Constipation
  • Loss of appetite
  • Brain fog
  • Dry mouth
  • Trouble sleeping

How To Use?

  • Kratom leaves either fresh or dried are made into tea, often chewed and seldom smoked.
  • Users mostly add lemon juice when making tea to enable the extraction of alkaloids.
  • You can add sugar or honey before drinking to cover the unpleasant flavor of the drink. The dried leaves are sometimes smoked.

Effects of Kratom Alkaloids:

Health-boosting alkaloids offer full health benefits by enhancing the strength and effectiveness of the product.

  • At high dosages, though, it can cause sedative-narcotic feelings.
  • At a low dose, kratom has stimulant effects and helps in combating exhaustion and tiredness throughout the extended working periods.

In traditional medicine, Kratom is useful for the treatment of opioid withdrawal symptoms and chronic pain and as an opium substitute Effects include;

  • Stimulation: it produces stimulation by acting on the three opiate receptors present in the brain.
  • Cognitive: It improves mental power, increase devotion width, enhances cognition skills, and makes you motivated and focus.
  • Painkilling Stroke: Due to analgesic action it helps in the destruction of the discomfort and soreness by generating endorphins and enkephalins in the pain pathway.
  • Muscle Relaxation: it can make you feel happy by soothes nerves and muscle relaxation and also reduces the stress.
  • Sedative: it has a sedative action if taken in higher quantities so useful for insomnia and other sleeping disorders due to the effect on the respiratory center positioned in the brain-stem.

Alkaloids cause significant physiological effects with your body chemistry, hence; used in medicines to cure different lousy health and medical conditions.